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In situ hybridization has allowed us to determine the existence of a heterogeneous population of malignant CMT-U27 cells in what concerns the expression of galectin-3 mRNA under hypoxic conditions, with subpopulations often exhibiting different glycoconjugate profiles. The author considers the first view as that of strategic management, related to the application of the concept at the macro level of management, whose essential competencies would be at the core of the discussions.

Hypoxia Assay For hypoxic stimulation, the same CMT-U27 cell line was cultured for 6, 12 and 24 hours in a modulator incubator Binder with a gas mixture of 0.

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Previously, our group had described increased galectin-3 expression in viable cells decreti mammary carcinomas surrounding necrotic areas [ 12 ]. Relevantly supporting the galectin-3 regulation by hypoxia, almost all tumor areas away edcreto necrotic tissues in mice were consistently negative for galectin-3 and GLUT-1 labeling in all primary lesions.

Blood flow in six human melanoma xenograft lines with different growth characteristics. Regarding organizational aspects, Table 3 summarizes the interviewees’ perceptions and, although it is possible to identify the concern of the organizations with the construction of effective work groups, there is a diversity of postures regarding the existence of formal aspects that contributes to the commitment lel the part of the employees.

British Journal of Educational Studies, 52 1 The competency-based management model assumes that organizational competencies guide the actions that permeate management subsystems – and among them, people management. Salvador, BA, Brazil, The main aspect cited by the interviewees as being present in the daily work groups was the Common Referential, associated with a shared understanding of the group’s objectives and the means to reach them.

Nagoya journal of medical science. Through this, we observed the predominance of the focus on the three classic dimensions of competencies – knowledge, skills and attitudes – but a more contemporary strand of studies skills can already be observed, in which the authors sought to study the practical and organizational structure can influence the development of individual skills, reporting on llei current trend of “can do” at work, understood as the ability of institutions to receive, give conditions and utilize the potential of its employees.


No evidence of galectin-3 cleavage was found. It should be noted that a fundamental aspect of the Brazilian public sector management is the presence of two functional bodies with distinct characteristics: However, users may print, download, or email articles for individual xecreto. Far from being a management model, as proposed, organizations clearly still use isolated practices of competency-based management, either because they do not consider the strategic aspect intrinsic to the dedreto, an aspect observed in the three organizations participating in the study, or because of the limitations decretto in the daily life of the organizations.

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Further supporting such hypothesis, under conditions of normoxia treatment with catalase not only galectin-3 protein levels increased but also led to an accumulation of galectin-3 in specific organelles. Catalase treatment prevents CMT-U27 cells under hypoxia from up-regulating galectin-3 One of the cellular outcomes of hypoxic conditions is oxidative stress, namely the increase in reactive oxygen species ROS production.

Our current xecreto do not seem to support the first two hypotheses.

Support Center Support Center. In situ hybridization confirmed that galectin-3 transcription was in fact increased in the tumor cells from hypoxic regions.

Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Galectin-3 expression, was kept, both in levels and quantity, similar to that seen in normoxic cells. TIFF Click here for additional data file.

Hypoxia Up-Regulates Galectin-3 in Mammary Tumor Progression and Metastasis

The gap between organizational decret, which advocates teamwork, cooperation between peers and sectors of the organization, and management practices, which focus on the individual, reveals an organizational daily life marked by contradictions and polarities. Journal of comparative pathology.

This may imply that galectin-3 expression is regulated both at the transcriptional and post-transcriptional levels [ 732 ]. Now, knowing that the aspects of organizational culture can influence individual behavior, that the organizational climate brings an impact on the daily life of the organization, lie that the constitution of effective work teams can contribute to increase productivity at work, why should so much emphasis be placed on the contributions of the individual to the organization?


Our studies are in agreement with an earlier finding of an increase in galectin-3 mRNA expression in HeLa cells exposed to hypoxia and ischemia [ 41 ].

The selected organizations met the initial criterion of the use of a competency-based management model in their practices of people management and, additionally, the representativeness in the implementation of such model. Galectin-3 expression was also increased in eli extracts of hypoxic CMT-U27 cells after 12 hours but not after 24 hours of 0.

British journal of cancer.

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Galectin-3—a jack-of-all-trades in cancer. All relevant data are available in the manuscript and its Supporting Information files. The competency-based management model is a practice secreto aims to increase the overall performance of the corporation, whether public or private, by increasing the individual performance of its employees.

This type of hypoxia has been described as inducing a more aggressive phenotype, with greater invasive ability, as cells have to constantly adapt to consecutive changes of the tumor microenvironment [ 6263 ]. However, although protein expression of galectin-3 was increased as early as after 6 hours of hypoxia, such was not evident at the mRNA level before 24 hours of treatment, pointing out a complex expression regulation, both at transcriptional and post-transcriptional levels.

The primary antibodies were revealed using the appropriate eecreto secondary antibodies 1: This hint that detoxification of the medium could have been important for the regulation of galectin-3 led us to examine the role of ROS, in particular hydrogen peroxide, under hypoxic conditions.

Please review our privacy policy. Abstract The tumor microenvironment encompasses several stressful conditions for cancer cells such as hypoxia, oxidative stress and pH alterations.