Description. Cremophor A 6 is a whitish waxy substance. Cremophor A 25 is supplied in the form of free-flowing, non-dusting microbeads. Identity. Cremophor A. August Supersedes issue dated May MEMC e/Page 1 of 8. Cremophor® A Grades. ® = Registered trademark of BASF Aktiengesellschaft. INCI: Ceteareth-6 (and) Stearyl AlcoholThe Cremophor A grades are Combinations of Cremophor A6 and Cremophor A25 can emulsify oils with a.
|Published (Last):||24 January 2010|
|PDF File Size:||14.53 Mb|
|ePub File Size:||11.1 Mb|
|Price:||Free* [*Free Regsitration Required]|
Br J Anaesth ; Pharmacological characteristics and side effects of a new galenic formulation of propofol without soyabean oil.
In vitro and in vivo evaluation of cyclic amino acid esters.
High Quality Cremophor A6 CAS NO 85941-44-2 ISO 22000 Verified Producer
In contrast to phospholipid emulsions, such polymeric micelles are more dynamic structures which in solution continuously exchange unimers isolated polymeric chains between the micellar structure and the free polymers in solution.
Another potential concern of cyclodextrins is cremoohor after release of the included drug, they may be able to bind coadministered lipophilic drugs. With our innovative products, we are contributing to finding solutions to some of the major challenges of our time. Dideu is a Life Science company with a long and glorious history and core competencies in the areas of health care and agriculture.
Despite the cremmophor success of propofol emulsions, there continue to be cremopuor associated with the current formulations. The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation Captisol versus x6 in a lipid formulation Diprivan: It may cause variations of propofol concentrations within a volume of emulsion due to creaming. At that size, a single droplet appears as a very crsmophor oil globule.
Selection of disodium edetate as the optimal antimicrobial additive for use in propofol emulsion. Ultimately, it is a complex interplay of intermolecular forces van der Waalsincluding thermodynamic hydrogen bonds and solvent hydrophobic interactions that allow stable inclusion complexes to be formed. Furthermore, whether clearance rates and different pathways of clearance, e. BASF products are tailor-made solution that helps to improve quality, increase comfort and reduce energy consumption, resulting in innovative solutions for the sustainable development of the industry.
Furthermore, it may lead to emboli upon emulsion intravenous administration because crmeophor presence of enlarged oil droplets or globules. The negative electrostatic repulsive forces are derived from small quantities of free fatty acids and phosphatidic acids in egg yolk lecithin.
Cremophor® A 6
China cas 9 China mini cas China fabric cas. Patented Propofol Emulsion Excipients.
Physicochemical compatibility of propofol-lidocaine mixture. Floyd AG, Jain S: You can manage this and all other alerts in My Account. Propofol formulation and pain on injection letter. As occurs with natural chylomicrons, some of these oil—lecithin—lipoprotein complexes are taken up by body tissues, and others attach to the capillary endothelial tissue in association with lipoprotein lipase. Effects of postoperative sedation with propofol and midazolam on pancreatic function assessed by pancreatitis-associated protein.
However, if the particle size were reduced to 0. Between andthe company invested 5. In early studies, it was found that pure phosphatidylcholine was a poor emulsifier compared with mixtures of phosphospholipids that occur naturally. This is characterized by metabolic acidosis, multiorgan failure, lipemia, hepatomegaly, rhabdomyolysis, and death. Chylomicron metabolism in an animal model for hyperlipoproteinemia type I. Increased acidity and the presence of electrolytes, e.
Pain on injection of propofol.
Cremophor® A 6 by BASF – Personal Care & Cosmetics
Not exactly what you want? The presence of albumin alone is known to aid in stabilization of the emulsions by steric or mechanical effects as well as by electrostatic repulsions due to negatively charged albumin. Role of formulation vehicles in taxane pharmacology. An additional factor may be lidocaine itself. This reformulation represented a significant improvement in intravenous propofol formulation and is the current mainstay of propofol delivery.
The hydrophilic brush border inhibits the attachment of these micelles to proteins. Pharm Res ; 8: Pharmacokinetics and pharmacodynamics of the new propofol prodrug GPI in rats. Food Chem Toxicol ; The growth of microorganisms in propofol and mixtures of propofol and lidocaine. Invest New Drugs ; Role of lipid in sulfite-dependent propofol dimerization. Eur J Crejophor ; Upon some collisions, attractive forces van der Waal interactions develop between droplets due to droplet surface imperfections.
This is primarily because of its rapid onset, short duration of action, and minimal side effects. Specifically, sulfite in this emulsion and at the concentrations present 0.
Major physical factors are increased temperature, agitation, and freeze—thawing. In view of these results, more study is needed to determine the effects of droplet enlargement and lipid aggregation on tissue perfusion from such infusions.