The maternal gene bicoid (bcd) organizes anterior development in Drosophila. Its mRNA is localized at the anterior tip of the oocyte and early. Request PDF on ResearchGate | A gradient of Bicoid protein in Drosophila embryos | The maternal gene bicoid (bcd) organizes anterior. A gradient in concentration of the protein product of the bicoid gene is a determinant of the anterior–posterior axis of Drosophila embryos.

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This paper has highly influenced 24 other papers.

From This Paper Topics from this paper. WieschausDavid W.

Bicoid is a maternal effect gene whose protein concentration gradient patterns the anterior-posterior A-P axis during Drosophila embryogenesis. Antibodies raised against bcd fusion proteins recognize a kd doublet band in Western blots of extracts of hr old embryos. Bicoid was also the first protein demonstrated to act as a morphogen.

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A gradient of bicoid protein in Drosophila embryos. – Semantic Scholar

The synthesis-diffusion-degradation model explains Bicoid gradient formation in unfertilized eggs. By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. Comparative phylogenetic [16] and experimental evolution [17] studies suggest an inherent mechanism for robust generation of a bcioid Bicoid protein gradient.


Tank Physical biology Mechanisms that have been proposed to effect this scaling include non-linear degradation of Bicoid, drsoophila nuclear retention as a size-dependent regulator of Bicoid protein’s effective diffusion coefficient, [9] [19] and scaling of cytoplasmic streaming.

Proceedings of the National Academy of Sciences. This page was last edited on 3 Novemberat The protein is concentrated in the nuclei of cleavage bicois embryos. Views Read Edit View history. Its mRNA is localized at the anterior tip of the oocyte and early embryo. DroccoEric F.

A gradient of bicoid protein in Drosophila embryos.

Skip to search form Skip to main content. Formation of the bicoid morphogen gradient: Bicoid is one of few proteins which binds both RNA and DNA targets using its homeodomain to regulate their transcription and translation, respectively. From Wikipedia, the free encyclopedia.

Citations Publications citing this paper. Showing of extracted citations. Topics Discussed in This Paper. Bicoid protein gradient formation is one of the earliest steps in fruit fly drosophilla A-P patterning: Multiple steps in the localization of bicoid RNA to the anterior pole of the Drosophila oocyte. By using this site, you agree to the Terms of Use and Privacy Policy.


Animal developmental biology Drosophila melanogaster genes.

A gradient of bicoid protein in Drosophila embryos. Morphogenesis, plasticity and irreversibility. The nucleic acid-binding homeodomain of Bicoid has been solved by NMR.

A gradient of bicoid protein in Drosophila embryos.

This paper has been referenced on Gradiient 2 times over the past 90 days. This protein is absent or reduced in embryonic extracts of nine of the 11 bcd alleles. Phosphorylation of bicoid on MAP-kinase sites: